Builder-Leader The AI Exoskeleton That Crosses the Gap. The book is outBuy on Amazon

Writing

Run Data Run is where I write about building with AI: experiments, what broke, and what it taught me. AIXplore holds the longer technical deep dives.

Latest · Oct 8, 2026

Google, Meta and the US Government Are Funding Biology's Next Open Dataset

Biohub, DOE, NIH, Google DeepMind, Isomorphic and Meta are pooling $1.8B to measure how cells respond to drugs and genes, and to release the data openly. Biology's last great open dataset ended up...

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Earlier posts (13) ↓
Sep 13, 2026
Anthropic Just Gave AI Agents a Driver for Your Lab Instruments

Two weeks after Anthropic's hardware standard shipped, the limits on a plate reader are prose in an agent prompt. Three questions to ask before yours gets a driver.

Sep 10, 2026
AlphaGenome Atlas and the Tools You Already Run

DeepMind precomputed every possible single-letter change in the human genome. I covered this model from the blog post last year. This time I read the preprint.

Sep 8, 2026
The Bottleneck Just Moved

OpenAI published two posts on the same Sunday. One counts everything it can measure about AI doing AI research. The other admits what it can't see. Together they say where the limit on progress now...

Aug 31, 2026
The Word I Didn't Write

I went on a podcast to argue that leaders have to build. The episode came out named after a word I used once, by accident, and it was the better idea.

Aug 11, 2026
Twenty-five years and half a mile

The morning before my first day I went for a run through Chicago, and a couple of miles in I recognised the route.

Aug 9, 2026
Take the Cast Off

Anthropic deleted more than 80% of Claude Code's system prompt and lost nothing they could measure. I ran the same test on my own instructions. I now know the answer for one file out of ninety-three.

Aug 4, 2026
I moved my whole AI coding setup to a model that costs 40 cents. Nobody noticed the difference.

A two-year-old harness, ported in an afternoon, for under forty cents. Then the model that did it wrote this post.

Jul 26, 2026
Somebody Is Finally Checking

A contest opened eleven days ago has produced more reproduction attempts than the field's own dedicated effort has managed in any year. Whether that becomes a check on the literature turns on a...

Jul 21, 2026
Nobody Saves Money on the Model

A team just swapped in a model that costs twice as much per token, and their bill went down. Here is why that is not a paradox, and what it means for anyone trying to make AI cheaper at scale.

Jul 20, 2026
The Failure That Leaves No Corpse

Your management apparatus is built for known unknowns. AI collaborators mostly produce the other kind.

Jul 20, 2026
Workflows, Seven Weeks In

I called the economics of fan-out the day it shipped. Running it as a daily default since taught me the caveat I buried in a footnote is the actual problem.

Jul 17, 2026
It Spreads Sideways. Someone Still Has to Light It.

Anthropic's Claude Code lead published a five-rung adoption ladder this week. Microsoft published the measurement fifteen days earlier, and the two do not agree about the size of the prize.

Jul 15, 2026
The Loop Is Simpler Than It Sounds

A dumb little trick that keeps its progress on your hard drive, not the model's head, and the three questions that decide whether it pays off or burns you while you sleep.

AIXplore

Technical deep dives

Reference material on architectures, implementations and emerging patterns.

41 more articles ↓
Technical article
Leading From The Other Side (The Month Three Checkpoint)
Technical article
From One Operator To A Team (The Phase Everyone Skips)
Technical article
Build A Free Audible Replacement In An Afternoon With Claude Code
Technical article
Build The Harness Out (Weeks 2 To 6)
Technical article
Bonsai 27B: Frontier Reasoning At 1.7 Bits A Weight
Technical article
Three Sessions, One Company: What Parallel AI Sessions Actually Cost
Technical article
Your First Saturday With Claude Code
Technical article
The Five Leadership Primitives Already Transfer
Technical article
Inventory Your Harness: The Six Components
Technical article
Maximizing Toward The Local Minimum: How Fast Optimization Drifts, And The Human Habit That Catches It
Technical article
Why Your Org Can&Apos;T Cross (Run Your Own Pilot Numbers)
Technical article
Hear The Three Tiers (And Name The Failure Mode)
Technical article
Which Side Of The Build Gap Are You On? (Run The Scorecard)
Technical article
The Harness That Wrote The Book
Technical article
Keeping The Node Smoking: What Eight H100s Buy, And The Engine That Keeps Them Full
Technical article
Sol Vs Terra Vs Luna: A Builder&Apos;S Guide To GPT 5.6
Technical article
Waking The Research Engine: Three Walls, One Experiment
Technical article
Day One: Standing Up The Inference Platform
Technical article
From A DGX Spark To A Borrowed Node: A Retinal AI Lab
Technical article
Two Camps Of Reasoning Post Training: Checkable Or Not
Technical article
The Composition Threshold: Bigger Library, Better Agent?
Technical article
Two Bets On Where Agent Context Lives
Technical article
Build An LLM Triage Layer That Can&Apos;T Freelance
Technical article
The Control Plane Bet: Code As Action In Search And Agents
Technical article
Mneme: Semantic Recall For Your Claude Code Sessions
Technical article
Managing A Homelab&Apos;S LLM API Keys With LiteLLM
Technical article
Standing Up A Homelab URL Shortener With Shlink
Technical article
Building Claude Code Skills By Conversation: Dossier Pattern
Technical article
Defending Your Homelab Fleet From Npm Supply Chain Attacks
Technical article
Codex Vs Claude Code Vs OpenCode: From Inside The Harness
Technical article
Anthropic Said &Apos;Feels Infinite.&Apos; Dreaming Is Where It Breaks
Technical article
RecursiveMAS And The End Of Text Mediated Agent Systems
Technical article
Teaching Gemma 4 E2B To Draft Like DFlash: A Build Log
Technical article
Reproducing Warp Decode: MoE Parallelism On Blackwell
Technical article
TurboQuant: 1,000 Experiments, One Uncomfortable Finding
Technical article
AutoResearch On Blackwell GB10: 151 Experiments Overnight
Technical article
Control Your Smart Home From The Terminal
Technical article
AI As Exoskeleton, Not Coworker: Human AI System Patterns
Technical article
The Model IS The Computer: Compute In Memory For AI
Technical article
Fix MacOS Window Chaos With Hammerspoon And Karabiner
Technical article
I Built An Autonomous AI Agent Squad For $10/Month