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ResearchactiveStarted April 2025

OncoVLM

Oncology multimodal AI models at three scales

92.4%
accuracy
4B, 1.7B, 500M
models

What it is

OncoVLM represents a systematic approach to building domain-specific multimodal AI for oncology. The project started with the hypothesis that smaller, focused models could outperform larger general-purpose models on specialized tasks.

The Multi-Scale Architecture

  • 4B parameter flagship model for comprehensive analysis
  • 1.7B parameter model balancing capability and efficiency
  • 500M parameter model for edge deployment and rapid inference

Training Methodology

Used multi-teacher knowledge distillation, combining insights from MedGemma (medical domain expertise), GPT-OSS-20B (general reasoning), and Qwen-3-30B (multilingual capabilities). This approach allowed the smaller models to inherit specialized knowledge from multiple larger teachers.

Key Results

  • 92.4% accuracy on PubMedQA benchmark
  • Outperforms general-purpose models of similar size on oncology tasks
  • Successfully handles multimodal inputs: pathology images, radiology, and clinical text

Technical Stack

Built on Gemma architecture with PaliGemma for vision encoding. Fine-tuned using LoRA for parameter efficiency, enabling training on DGX Spark's 128GB VRAM. The distillation pipeline runs automated experiments using the Autonomous Researcher framework.

Connected work

What it touches